Stopping HIV fusion with enfuvirtide: the first step to extracellular HAART.
نویسنده
چکیده
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منابع مشابه
Impact of vitamin supplements on HAART related hematological abnormalities in HIV-infected patients
Background: The human immunodeficiency virus (HIV) is one of the most life- threatening human infections. The advent of highly active antiretroviral therapy (HAART) has dramatically changed the course of HIV infection and patients' quality of life. In addition to the benefits, HAART can have numerous side effects and toxicities. Therefore, we aimed to assess the impact of short-term vitamins tr...
متن کاملClinical perspective of fusion inhibitors for treatment of HIV.
The number of antiretroviral-experienced HIV patients with multiple resistances against the currently available antiretroviral drug classes is increasing substantially. Therapeutic options for this specific group of patients are limited. The fusion inhibitor enfuvirtide represents the first new therapeutic option from a new drug class for this patient population. An optimized background therapy...
متن کاملDepletion of latent HIV-1 infection in vivo: a proof-of-concept study.
BACKGROUND Persistent infection in resting CD4+ T cells prevents eradication of HIV-1. Since the chromatin remodeling enzyme histone deacetylase 1 (HDAC1) maintains latency of integrated HIV, we tested the ability of the HDAC inhibitor valproic acid to deplete persistent, latent infection in resting CD4+ T cells. PROCEDURES We did a proof-of-concept study in four volunteers infected with HIV ...
متن کاملDiscontinuation of enfuvirtide in heavily pretreated HIV-infected individuals.
BACKGROUND Enfuvirtide was shown to be highly effective in treatment- experienced patients. Data on discontinuation of enfuvirtide and switch to new antiretroviral drugs are scarce. We aimed to evaluate the efficacy and the impact of discontinuing and/or switching enfuvirtide on virologic and clinical parameters in clinical practice. METHODS All HIV-infected individuals participating in the S...
متن کاملPutative role of membranes in the HIV fusion inhibitor enfuvirtide mode of action at the molecular level.
Partition of the intrinsically fluorescent HIV fusion inhibitor enfuvirtide into lipidic membranes is relatively high (Delta G =6.6 kcal x mol(-1)) and modulated by cholesterol. A shallow position in the lipidic matrix makes it readily available for interaction with gp41. No conformational energetic barrier prevents enfuvirtide from being active in both aqueous solution and lipidic membranes. L...
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ورودعنوان ژورنال:
- The Journal of antimicrobial chemotherapy
دوره 51 2 شماره
صفحات -
تاریخ انتشار 2003